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The Briefs article highlights that scientists are concerned about how methamphetamine use may impact of the body's ability to fight infection and sustain well-being, especially with regards to handling HIV infection.
Methamphetamine, especially when it has been combined with other drugs, is very damaging to the brain. In the studies of gay men, the use of methamphetamine was often associated with increased risk of HIV infection, elevated viral load, and comparatively low CD4 cell count.
The impact of meth use on CD4 cell count also was seen to be related to the particular methamphetamine preparation being used. In one of the studies, persons who used an earlier generation methamphetamine preparation (crystal methamphetamine) were found to have a 30 percent greater chance of having a CD4 cell count less than 200 cells/µL than those who used methamphetamine hydrochloride
This study emphasizes that methamphetamine use can have serious serious health implications, even among people who are well-controlled on treatment for HIV. In the USA, methamphetamine is on the radar of both federal and state agencies for its permissibility of control, in addition to some concern over methamphetamine use in the population of young gay men. Some worry that methamphetamine use in HIV-positive gay men is linked to increasing rates of methamphetamine abuse.
The evidence shows that the use of methamphetamine cuts the levels of natural killer cells, which are instrumental in attacking and killing HIV, and promotes the production of two anti-HIV proteins in the brain called Tat and Rev.
Methamphetamine also enhances the viral replication of HIV in the central nervous system, so it is important that treatment for HIV be combined with antiretroviral drugs that target the central nervous system as well. Efforts to combat methamphetamine's impact on HIV replication should take precedence over concerns about whether methamphetamine use can affect the ability of infected people to control HIV infection. d2c66b5586