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The seven studies chosen for evaluation were randomized, double-blind, bilateral paired comparison trials that examined the effects of two topical products in patients with bilateral foot xerosis. Patients served as their own controls, with the intervention applied to one foot and the comparator to the opposite foot. Five studies explicitly instructed patients to apply each intervention twice daily,13,15-18 whereas the others did not mention a specific dosing frequency.6,14 Xerosis was evaluated using a variety of scales that were either four-point or seven-point scales, with higher scores indicating more dryness. More details about the studies are provided in TABLE 1.

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