At the 2011 ASCO annual meeting, the results of a phase II study on the role of small interferon-alpha subtype 2 (IFN-α2) in thyroid cancer were presented. In this study, 29 patients with advanced thyroid cancer (n=25) or advanced melanoma (n=4) were treated with 5 million units of IFN-α2 three times a week for 2 weeks, followed by 2 weeks of rest.
The 2011 ASCO annual meeting also presented the results of the phase II sunitinib study presented above. A total of 54 patients with advanced iodine-refractory thyroid cancer were treated, mainly with a median duration of 17 weeks. Stable disease for >6 months was observed in 13 patients, and objective response was observed in 5 patients. The most frequent grade 3/4 adverse events were hand-foot syndrome, fatigue, nausea, diarrhea, stomatitis, hypertension and vomiting .
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One of the drawbacks to this approach was that we needed to recompile every time we made even a small change to the code. This slowed everything else we were doing down and because we couldn't always have someone waiting for the application to finish building. 827ec27edc